Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5

Although the treatment of brain tumors by targeting kinase-regulated macroautophagy/autophagy, is under investigation, the precise mechanism underlying autophagy initiation and its significance in glioblastoma (GBM) remains to be defined. Here, we report that PAK1 (p21 [RAC1] activated kinase 1) is...

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Publicat a:Autophagy
Autors principals: Feng, Xing, Zhang, Heng, Meng, Lingbing, Song, Huiwen, Zhou, Qingxin, Qu, Chao, Zhao, Pan, Li, Qinghua, Zou, Chang, Liu, Xing, Zhang, Zhiyong
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032228/
https://ncbi.nlm.nih.gov/pubmed/32186433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1731266
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