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In vivo comet assay in rabbit corneal epithelial cells following ocular instillation with genotoxic compounds

BACKGROUND: The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, the levels of systemic drug exposure following systemic administration are of...

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Publié dans:Genes Environ
Auteurs principaux: Tahara, Haruna, Yamagiwa, Yoshinori, Haranosono, Yu, Kurata, Masaaki
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028091/
https://ncbi.nlm.nih.gov/pubmed/33827709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-021-00184-4
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