Targeting cartilage EGFR pathway for osteoarthritis treatment

Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying treatments. Previously, we found that mice with cartilage-specific epidermal growth factor receptor (EGFR) deficiency developed accelerated knee OA. To test whether the EGFR pathway can be targeted as a potent...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Wei, Yulong, Luo, Lijun, Gui, Tao, Yu, Feifan, Yan, Lesan, Yao, Lutian, Zhong, Leilei, Yu, Wei, Han, Biao, Patel, Jay M., Liu, Jessica F., Beier, Frank, Levin, Lawrence Scott, Nelson, Charles, Shao, Zengwu, Han, Lin, Mauck, Robert L., Tsourkas, Andrew, Ahn, Jaimo, Cheng, Zhiliang, Qin, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027922/
https://ncbi.nlm.nih.gov/pubmed/33441426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abb3946
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