Loss of FoxO3a prevents aortic aneurysm formation through maintenance of VSMC homeostasis

Vascular smooth muscle cell (VSMC) phenotypic switching plays a critical role in the formation of abdominal aortic aneurysms (AAAs). FoxO3a is a key suppressor of VSMC homeostasis. We found that in human and animal AAA tissues, FoxO3a was upregulated, SM22α and α-smooth muscle actin (α-SMA) proteins...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Lu, Weiling, Zhou, Yu, Zeng, Shan, Zhong, Lintao, Zhou, Shiju, Song, Haoyu, Ding, Rongming, Zhong, Gaojun, Li, Qingrui, Hu, Yuhua, Wen, Zhongyu, Liao, Qin, Wang, Yalan, Lyu, Lianglliang, Zhong, Yiming, Hu, Gonghua, Liao, Yulin, Xie, Dongming, Xie, Jiahe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027644/
https://ncbi.nlm.nih.gov/pubmed/33828087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03659-y
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