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Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity
IL-2 is the master-regulator cytokine for T cell dependent responses and is crucial for proliferation and survival of T cells. However, IL-2-based treatments remained marginal, in part due to short half-life. Thus, we aimed to extend IL-2 half-life by flanking the IL-2 core with sequences derived fr...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8027413/ https://ncbi.nlm.nih.gov/pubmed/33828163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87102-4 |
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