Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity

IL-2 is the master-regulator cytokine for T cell dependent responses and is crucial for proliferation and survival of T cells. However, IL-2-based treatments remained marginal, in part due to short half-life. Thus, we aimed to extend IL-2 half-life by flanking the IL-2 core with sequences derived fr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ottolenghi, Aner, Bolel, Priyanka, Sarkar, Rhitajit, Greenshpan, Yariv, Iraqi, Muhammed, Ghosh, Susmita, Bhattacharya, Baisali, Taylor, Zoe V., Kundu, Kiran, Radinsky, Olga, Gazit, Roi, Stepensky, David, Apte, Ron N., Voronov, Elena, Porgador, Angel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027413/
https://ncbi.nlm.nih.gov/pubmed/33828163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87102-4
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