RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis

Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational modifications (PTM)-based mechanism for the inactivation of RUNX3 under hypoxia is still not fully understood. Here, we demonstrate a mechanism...

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Publicat a:Cell Death Differ
Autors principals: Lee, Sun Hee, Hyeon, Do Young, Yoon, Soo-Hyun, Jeong, Ji-Hak, Han, Saeng-Myung, Jang, Ju-Won, Nguyen, Minh Phuong, Chi, Xin-Zi, An, Sojin, Hyun, Kyung-gi, Jung, Hee-Jung, Song, Ji-Joon, Bae, Suk-Chul, Kim, Woo-Ho, Hwang, Daehee, Lee, You Mie
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027031/
https://ncbi.nlm.nih.gov/pubmed/33116296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00647-1
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