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Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor

Previous studies have shown the presence of several subunits of the inhibitory glycine receptor (GlyR) in the reward system, specifically in medium spiny neurons (MSNs) of the nucleus Accumbens (nAc). It was suggested that GlyR α1 subunits regulate nAc excitability and ethanol consumption. However,...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Gallegos, S., San Martin, L., Araya, A., Lovinger, D. M., Homanics, G. E., Aguayo, L. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026987/
https://ncbi.nlm.nih.gov/pubmed/32357359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-0689-9
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