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Drosophila RASopathy models identify disease subtype differences and biomarkers of drug efficacy
RASopathies represent a family of mostly autosomal dominant diseases that are caused by missense variants in the rat sarcoma viral oncogene/mitogen activated protein kinase (RAS/MAPK) pathway including KRAS, NRAS, BRAF, RAF1, and SHP2. These variants are associated with overlapping but distinct phen...
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| Udgivet i: | iScience |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026909/ https://ncbi.nlm.nih.gov/pubmed/33855281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102306 |
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