Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus

Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity. It has a well-defined safety profile and is being assessed in late-stage clinical trials. Howeve...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Oncolytics
Hauptverfasser: Hill, Claudia, Grundy, Megan, Bau, Luca, Wallington, Sheena, Balkaran, Joel, Ramos, Victor, Fisher, Kerry, Seymour, Len, Coussios, Constantin, Carlisle, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026752/
https://ncbi.nlm.nih.gov/pubmed/33869742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2021.03.011
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