Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells

Histone crotonylation is a non-acetyl histone lysine modification that is as widespread as acetylation. However, physiological functions associated with histone crotonylation remain almost completely unknown. Here we report that histone crotonylation is crucial for endoderm differentiation. We demon...

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Udgivet i:Cell Stem Cell
Main Authors: Fang, Yi, Xu, Xiaojiang, Ding, Jun, Yang, Lu, Doan, Mary T., Karmaus, Peer W.F., Snyder, Nathaniel W., Zhao, Yingming, Li, Jian-Liang, Li, Xiaoling
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026719/
https://ncbi.nlm.nih.gov/pubmed/33450185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.12.009
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