Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis

During sepsis, neutrophil activation induces endothelial cell (EC) dysfunction partly through neutrophil extracellular trap (NET) release. The triggering receptor expressed on myeloid cell-1 (TREM-1) is an orphan immune receptor that amplifies the inflammatory response mediated by Toll-like receptor...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Immunol
Prif Awduron: Boufenzer, Amir, Carrasco, Kevin, Jolly, Lucie, Brustolin, Benjamin, Di-Pillo, Elisa, Derive, Marc, Gibot, Sébastien
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026640/
https://ncbi.nlm.nih.gov/pubmed/33420354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00591-7
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