Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by an extensive fibroinflammatory stroma, which includes abundant cancer-associated fibroblast (CAF) populations. PDAC CAFs are heterogeneous, but the nature of this heterogeneity is incompletely understood. The Hedge...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Steele, Nina G., Biffi, Giulia, Kemp, Samantha B., Zhang, Yaqing, Drouillard, Donovan, Syu, LiJyun, Hao, Yuan, Oni, Tobiloba E., Brosnan, Erin, Elyada, Ela, Doshi, Abhishek, Hansma, Christa, Espinoza, Carlos, Abbas, Ahmed, The, Stephanie, Irizarry-Negron, Valerie, Halbrook, Christopher J., Franks, Nicole E., Hoffman, Megan T., Brown, Kristee, Carpenter, Eileen S., Nwosu, Zeribe C., Johnson, Craig, Lima, Fatima, Anderson, Michelle A., Park, Youngkyu, Crawford, Howard C., Lyssiotis, Costas A., Frankel, Timothy L., Rao, Arvind, Bednar, Filip, Dlugosz, Andrzej A., Preall, Jonathan B., Tuveson, David A., Allen, Benjamin L., di Magliano, Marina Pasca
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026631/
https://ncbi.nlm.nih.gov/pubmed/33495315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3715
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