Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice

Mitophagy is a selective form of autophagy involving the removal of damaged mitochondria via the autophagy-lysosome pathway. PINK1-Parkin-mediated mitophagy is one of the most important mechanisms in cardiovascular disease, cerebral ischemia-reperfusion (I/R) injury, and neurodegenerative diseases....

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Wu, Man, Lu, Guang, Lao, Yuan-zhi, Zhang, Hong, Zheng, Dan, Zheng, Zhao-qing, Yi, Juan, Xiang, Qian, Wang, Li-ming, Tan, Hong-sheng, Zhou, Hua, Shen, Han-ming, Xu, Hong-xi
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Singapore 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026581/
https://ncbi.nlm.nih.gov/pubmed/32759963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-0480-9
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