Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias

Patients with myelodysplastic syndromes (MDS) display severe anemia but the mechanisms underlying this phenotype are incompletely understood. Right open-reading-frame kinase 2 (RIOK2) encodes a protein kinase located at 5q15, a region frequently lost in MDS del(5q) patients. Here, we show that hemat...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Raundhal, Mahesh, Ghosh, Shrestha, Myers, Samuel A., Cuoco, Michael S., Singer, Meromit, Carr, Steven A., Waikar, Sushrut S., Bonventre, Joseph V., Ritz, Jerome, Stone, Richard M., Steensma, David P., Regev, Aviv, Glimcher, Laurie H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026551/
https://ncbi.nlm.nih.gov/pubmed/33753942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00895-4
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