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Mechanisms underlying age-associated manifestation of cardiac sodium channel gain-of-function
Cardiac action potentials are initiated by sodium ion (Na(+)) influx through voltage-gated Na(+) channels. Na(+) channel gain-of-function (GOF) can arise in inherited conditions due to mutations in the gene encoding the cardiac Na(+) channel, such as Long QT syndrome type 3 (LQT3). LQT3 can be a “co...
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| Опубликовано в: : | J Mol Cell Cardiol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026540/ https://ncbi.nlm.nih.gov/pubmed/33373643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2020.12.008 |
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