Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy

Hyperglycemia is a key determinant for development of diabetic retinopathy (DR). Inadequate glycemic control exacerbates retinopathy, while normalization of glucose levels delays its progression. In hyperglycemia, hexokinase is saturated and excess glucose is metabolized to sorbitol by aldose reduct...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Holoman, Nicholas C., Aiello, Jacob J., Trobenter, Timothy D., Tarchick, Matthew J., Kozlowski, Michael R., Makowski, Emily R., De Vivo, Darryl C., Singh, Charandeep, Sears, Jonathan E., Samuels, Ivy S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026348/
https://ncbi.nlm.nih.gov/pubmed/33622781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2010-20.2021
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