Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy

Hyperglycemia is a key determinant for development of diabetic retinopathy (DR). Inadequate glycemic control exacerbates retinopathy, while normalization of glucose levels delays its progression. In hyperglycemia, hexokinase is saturated and excess glucose is metabolized to sorbitol by aldose reduct...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Holoman, Nicholas C., Aiello, Jacob J., Trobenter, Timothy D., Tarchick, Matthew J., Kozlowski, Michael R., Makowski, Emily R., De Vivo, Darryl C., Singh, Charandeep, Sears, Jonathan E., Samuels, Ivy S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2021
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026348/
https://ncbi.nlm.nih.gov/pubmed/33622781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2010-20.2021
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