EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway

BACKGROUND: Epithelial to mesenchymal transition (EMT) contributes to tumor metastasis and chemoresistance. Eukaryotic initiation factor 5A2 (EIF5A2) is highly expressed in a variety of human cancers but rarely expressed in normal tissues. While EIF5A2 has oncogenic activity in several cancers and c...

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Vydáno v:Cell Biosci
Hlavní autoři: Zhao, Guannan, Zhang, Wenjing, Dong, Peixin, Watari, Hidemichi, Guo, Yuqi, Pfeffer, Lawrence M., Tigyi, Gabor, Yue, Junming
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025533/
https://ncbi.nlm.nih.gov/pubmed/33827661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00578-5
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