miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway

BACKGROUND: We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting epithelial to mesenchymal transition (EMT), whereas BIRC5/survivin promotes EMT. In this study, we tested our hypothesis that miR-20...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Wang, Baojin, Li, Xia, Zhao, Guannan, Yan, Huan, Dong, Peixin, Watari, Hidemichi, Sims, Michelle, Li, Wei, Pfeffer, Lawrence M, Guo, Yuqi, Yue, Junming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150978/
https://ncbi.nlm.nih.gov/pubmed/30241553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0906-0
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