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An Improved Process for the Palladium-Catalyzed C–O Cross-Coupling of Secondary Alcohols

An improved protocol for the Pd-catalyzed C–O cross-coupling of secondary alcohols is described. The use of biaryl phosphine L2 as the ligand was key to achieving efficient cross-coupling of (hetero)aryl chlorides with only a 20% molar excess of the alcohol. Additionally, we observed an unusual reac...

詳細記述

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書誌詳細
出版年:Org Lett
主要な著者: Zhang, Hong, Ruiz-Castillo, Paula, Schuppe, Alexander W., Buchwald, Stephen L.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025245/
https://ncbi.nlm.nih.gov/pubmed/32579375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c01668
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