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DNA topoisomerase 3 is required for efficient germ cell quality control

An important quality control mechanism eliminates meiocytes that have experienced recombination failure during meiosis. The culling of defective oocytes in Caenorhabditis elegans meiosis resembles late oocyte elimination in female mammals. Here we show that topoisomerase 3 depletion generates DNA le...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Dello Stritto, Maria Rosaria, Bauer, Bernd, Barraud, Pierre, Jantsch, Verena
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025215/
https://ncbi.nlm.nih.gov/pubmed/33798260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202012057
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