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Discovery of rare sulfated N-unsubstituted glucosamine based heparan sulfate analogs selectively activating chemokines

Achieving selective inhibition of chemokines with structurally well-defined heparan sulfate (HS) oligosaccharides can provide important insights into cancer cell migration and metastasis. However, HS is highly heterogeneous in chemical composition, which limits its therapeutic use. Here, we report t...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Chem Sci
Päätekijät: Jain, Prashant, Shanthamurthy, Chethan D., Leviatan Ben-Arye, Shani, Woods, Robert J., Kikkeri, Raghavendra, Padler-Karavani, Vered
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royal Society of Chemistry 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025211/
https://ncbi.nlm.nih.gov/pubmed/33889380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05862a
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