p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model

BACKGROUND & AIMS: A coordinated stress and regenerative response is important after hepatocyte damage. Here, we investigate the phenotypes that result from genetic abrogation of individual components of the checkpoint kinase 2/transformation-related protein 53 (p53)/cyclin-dependent kinase inhi...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Buitrago-Molina, Laura Elisa, Marhenke, Silke, Becker, Diana, Geffers, Robert, Itzel, Timo, Teufel, Andreas, Jaeschke, Hartmut, Lechel, André, Unger, Kristian, Markovic, Jovana, Sharma, Amar Deep, Marquardt, Jens U., Saborowski, Michael, Saborowski, Anna, Vogel, Arndt
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024980/
https://ncbi.nlm.nih.gov/pubmed/33484913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.01.006
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