p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model

BACKGROUND & AIMS: A coordinated stress and regenerative response is important after hepatocyte damage. Here, we investigate the phenotypes that result from genetic abrogation of individual components of the checkpoint kinase 2/transformation-related protein 53 (p53)/cyclin-dependent kinase inhi...

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Publicat a:Cell Mol Gastroenterol Hepatol
Autors principals: Buitrago-Molina, Laura Elisa, Marhenke, Silke, Becker, Diana, Geffers, Robert, Itzel, Timo, Teufel, Andreas, Jaeschke, Hartmut, Lechel, André, Unger, Kristian, Markovic, Jovana, Sharma, Amar Deep, Marquardt, Jens U., Saborowski, Michael, Saborowski, Anna, Vogel, Arndt
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024980/
https://ncbi.nlm.nih.gov/pubmed/33484913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.01.006
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