CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia

β-thalassemia, an autosomal recessive blood disorder that reduces the production of hemoglobin, is majorly caused by the point mutation of the HBB gene resulting in reduced or absent β-globin chains of the hemoglobin tetramer. Animal models recapitulating both the phenotype and genotype of human dis...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Yang, Yi, Kang, Xiangjin, Hu, Shiqi, Chen, Bangzhu, Xie, Yingjun, Song, Bing, Zhang, Quanjun, Wu, Han, Ou, Zhanhui, Xian, Yexing, Fan, Yong, Li, Xiaoping, Lai, Liangxue, Sun, Xiaofang
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2021
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024976/
https://ncbi.nlm.nih.gov/pubmed/33639162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100464
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