CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia

β-thalassemia, an autosomal recessive blood disorder that reduces the production of hemoglobin, is majorly caused by the point mutation of the HBB gene resulting in reduced or absent β-globin chains of the hemoglobin tetramer. Animal models recapitulating both the phenotype and genotype of human dis...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Yang, Yi, Kang, Xiangjin, Hu, Shiqi, Chen, Bangzhu, Xie, Yingjun, Song, Bing, Zhang, Quanjun, Wu, Han, Ou, Zhanhui, Xian, Yexing, Fan, Yong, Li, Xiaoping, Lai, Liangxue, Sun, Xiaofang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024976/
https://ncbi.nlm.nih.gov/pubmed/33639162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100464
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