A human ACTH-secreting corticotroph tumoroid model: Novel Human ACTH-Secreting Tumor Cell in vitro Model

BACKGROUND: Cushing disease (CD), although rare, is a life-threatening disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma, which leads to excess adrenal-derived cortisol. Efficacious and safe medical therapies that control both hormonal hypersecretion and pituitary...

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Bibliographic Details
Published in:EBioMedicine
Main Authors: Zhang, Dongyun, Hugo, Willy, Redublo, Peter, Miao, Hui, Bergsneider, Marvin, Wang, Marilene B., Kim, Won, Yong, William H., Heaney, Anthony P.
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024915/
https://ncbi.nlm.nih.gov/pubmed/33773184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103294
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