SAT-311 Role of SREBP in Regulation of Corticotroph Tumor ACTH Secretion and Cell Proliferation

Cushing Disease (CD) is a life-threatening condition with suboptimal medical treatment. To identify drugs that not only inhibit ACTH secretion to attain eucortisolemia but also inhibit tumor growth, we conducted a high throughput screen employing a novel “gain of signal” ACTH AlphaLISA assay. From a...

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Vydáno v:J Endocr Soc
Hlavní autoři: Zhang, Dongyun, Damoiseaux, Robert, Bergsneider, Marvin, Wang, Marilene B, Yong, William H, Kelly, Kathleen A, Heaney, Anthony P
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Neuroendocrinology and Pituitary
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208152/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1628
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