Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins

Lysosome-related organelles (LROs) are endosomal compartments carrying tissue-specific proteins, which become enlarged in Chediak-Higashi syndrome (CHS) due to mutations in LYST. Here, we show that Drosophila Mauve, a counterpart of LYST, suppresses vesicle fusion events with lipid droplets (LDs) du...

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Vydáno v:Dev Cell
Hlavní autoři: Lattao, Ramona, Rangone, Hélène, Llamazares, Salud, Glover, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024676/
https://ncbi.nlm.nih.gov/pubmed/33725482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.02.019
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