Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase

UDP-glucose:glycoprotein glucosyltransferase (UGGT) flags misfolded glycoproteins for ER retention. We report crystal structures of full-length Chaetomium thermophilum UGGT (CtUGGT), two CtUGGT double-cysteine mutants, and its TRXL2 domain truncation (CtUGGT-ΔTRXL2). CtUGGT molecular dynamics (MD) s...

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Gepubliceerd in:Structure
Hoofdauteurs: Modenutti, Carlos P., Blanco Capurro, Juan I., Ibba, Roberta, Alonzi, Dominic S., Song, Mauro N., Vasiljević, Snežana, Kumar, Abhinav, Chandran, Anu V., Tax, Gabor, Marti, Lucia, Hill, Johan C., Lia, Andrea, Hensen, Mario, Waksman, Thomas, Rushton, Jonathan, Rubichi, Simone, Santino, Angelo, Martí, Marcelo A., Zitzmann, Nicole, Roversi, Pietro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024514/
https://ncbi.nlm.nih.gov/pubmed/33352114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.11.017
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