Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins

The enzyme UDP-glucose:glycoprotein glucosyltransferase (UGGT) mediates quality control of glycoproteins in the endoplasmic reticulum by attaching glucose to N-linked glycan of misfolded proteins. As a sensor, UGGT ensures that misfolded proteins are recognized by the lectin chaperones and do not le...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Calles-Garcia, Daniel, Yang, Meng, Soya, Naoto, Melero, Roberto, Ménade, Marie, Ito, Yukishige, Vargas, Javier, Lukacs, Gergely L., Kollman, Justin M., Kozlov, Guennadi, Gehring, Kalle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500813/
https://ncbi.nlm.nih.gov/pubmed/28490633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789495
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