Reglucosylation by UDP-glucose:glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not degradation

UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) is a central quality control gatekeeper in the mammalian endoplasmic reticulum (ER). The reglucosylation of glycoproteins supports their rebinding to the carbohydrate-binding ER molecular chaperones calnexin and calreticulin. A cell-based regluco...

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發表在:Mol Biol Cell
Main Authors: Tannous, Abla, Patel, Nishant, Tamura, Taku, Hebert, Daniel N.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310732/
https://ncbi.nlm.nih.gov/pubmed/25428988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-08-1254
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