Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression

Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we found that single p53 allele loss specifically impacted the oxidative, DNA dama...

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Publicado no:Cell Death Dis
Main Authors: Marruecos, Laura, Manils, Joan, Moreta, Cristina, Gómez, Diana, Filgaira, Ingrid, Serafin, Anna, Cañas, Xavier, Espinosa, Lluís, Soler, Concepció
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024389/
https://ncbi.nlm.nih.gov/pubmed/33824284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03638-3
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