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Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase

Human manganese superoxide dismutase is a critical oxidoreductase found in the mitochondrial matrix. Concerted proton and electron transfers are used by the enzyme to rid the mitochondria of O(2)(•−). The mechanisms of concerted transfer enzymes are typically unknown due to the difficulties in detec...

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Publicat a:Nat Commun
Autors principals: Azadmanesh, Jahaun, Lutz, William E., Coates, Leighton, Weiss, Kevin L., Borgstahl, Gloria E. O.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024262/
https://ncbi.nlm.nih.gov/pubmed/33824320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22290-1
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