Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast cancer cells to EGF by monitoring phosphoproteome...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Vemulapalli, Vidyasiri, Chylek, Lily A, Erickson, Alison, Pfeiffer, Anamarija, Gabriel, Khal-Hentz, LaRochelle, Jonathan, Subramanian, Kartik, Cao, Ruili, Stegmaier, Kimberley, Mohseni, Morvarid, LaMarche, Matthew J, Acker, Michael G, Sorger, Peter K, Gygi, Steven P, Blacklow, Stephen C
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2021
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024022/
https://ncbi.nlm.nih.gov/pubmed/33755016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64251
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk