Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis

OBJECTIVES: How insulin-like growth factor-1 (IGF-1) is related to OA is not well understood. We determined relationships between IGF-1 and hospital-diagnosed hand, hip and knee OA in UK Biobank, using Mendelian randomization (MR) to determine causality. METHODS: Serum IGF-1 was assessed by chemilum...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Hartley, April, Sanderson, Eleanor, Paternoster, Lavinia, Teumer, Alexander, Kaplan, Robert C, Tobias, Jon H, Gregson, Celia L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023994/
https://ncbi.nlm.nih.gov/pubmed/33027520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa597
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