Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice

OBJECTIVE: High levels of IL-22 are present in serum and synovial fluid of patients with RA. As both pro- and anti-inflammatory roles for IL-22 have been described in studies using animal models of RA, its exact function in arthritis remains poorly defined. With this study we aimed to further unrave...

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Bibliografiske detaljer
Udgivet i:Rheumatology (Oxford)
Main Authors: Aarts, Joyce, Roeleveld, Debbie M, Helsen, Monique M, Walgreen, Birgitte, Vitters, Elly L, Kolls, Jay, van de Loo, Fons A, van Lent, Peter L, van der Kraan, Peter M, Koenders, Marije I
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Basic and Translational Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023992/
https://ncbi.nlm.nih.gov/pubmed/33197269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa589
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