Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis

Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β and IL-6 or IL-21, and can be reduced in the absence of either IL-6 or IL-21. The aim...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Roeleveld, Debbie M., Marijnissen, Renoud J., Walgreen, Birgitte, Helsen, Monique M., van den Bersselaar, Liduine, van de Loo, Fons A., van Lent, Peter L., van der Kraan, Peter M., van den Berg, Wim B., Koenders, Marije I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291406/
https://ncbi.nlm.nih.gov/pubmed/28158305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171757
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