pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer

Multidrug resistance (MDR) is one of the main reasons for tumor chemotherapy failure. Podophyllotoxin (PPT) has been reported that can suppress MDR cancer cell growth; however, effective delivery of PPT to MDR cancer cells is challenged by cascaded bio-barriers. To effectively deliver PPT to MDR can...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Deliv
Hauptverfasser: Li, Chao, Wang, Yifan, Zhang, Shuo, Zhang, Jiaojiao, Wang, Fang, Sun, Yunhao, Huang, Lirong, Bian, Wen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023596/
https://ncbi.nlm.nih.gov/pubmed/33818237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1905750
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