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A concise Diels–Alder strategy leading to congeners of the ABC ring system of the marine alkaloid ‘upenamide

A second-generation approach to the BC spirocycle of ‘upenamide is reported. Central to the synthesis is an endo selective Diels–Alder reaction between 1-(t-butyldimethylsiloxy)-1,3-butadiene and bromomaleic anhydride followed by a radical mediated allylation of the ring fusion bromide. Functional g...

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Detalhes bibliográficos
Publicado no:Tetrahedron Lett
Main Authors: Wenzler, Marta E., Melancon, Bruce J., Sulikowski, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023302/
https://ncbi.nlm.nih.gov/pubmed/33828342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2016.05.102
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