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License to kill: microsatellite instability and immune contexture

Colorectal cancers (CRCs) with microsatellite instability (MSI) are due to a defect in the DNA mismatch repair (MMR) system resulting in an accumulation of frame-shift mutations. They are characterized by a tumor microenvironment richer in cytotoxic CD8 T-cells (CTLs) and a better prognosis compared...

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Détails bibliographiques
Publié dans:Oncoimmunology
Auteurs principaux: Maby, Pauline, Bindea, Gabriela, Mlecnik, Bernhard, Galon, Jérôme
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023238/
https://ncbi.nlm.nih.gov/pubmed/33868790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1905935
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