Increased long QT and Torsade de pointes reporting on tamoxifen compared to aromatase inhibitors.

OBJECTIVE. A prolonged QTc (LQT) is a surrogate for the risk of Torsade-de-Pointes (TdP). QTc interval duration is influenced by sex hormones: estradiol prolongs and testosterone shortens QTc. Drugs used in the treatment of breast cancer have divergent effects on hormonal status. METHODS. We perform...

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Veröffentlicht in:Heart
Hauptverfasser: Grouthier, Virginie, Lebrun-Vignes, Benedicte, Glazer, Andrew, Touraine, Philippe, Funck-Brentano, Christian, Pariente, Antoine, Courtillot, Carine, Bachelot, Anne, Roden, Dan M., Moslehi, Javid J., Salem, Joe-Elie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022857/
https://ncbi.nlm.nih.gov/pubmed/29720397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/heartjnl-2017-312934
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