Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) is the most common cause of death worldwide. The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome plays an important role in the inflammatory response to MIRI. Dexmedetomidine (DEX), a specific agonist of α2-adrenergic re...

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Publicado en:BMC Anesthesiol
Main Authors: Huang, Yaru, Sun, Xiaotong, Juan, Zhaodong, Zhang, Rui, Wang, Ruoguo, Meng, Shuqi, Zhou, Jiajia, Li, Yan, Xu, Keyou, Xie, Keliang
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022424/
https://ncbi.nlm.nih.gov/pubmed/33823789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-021-01334-5
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