Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome

Activation of the NLRP3 inflammasome by Leishmania parasites is critical for the outcome of leishmaniasis, a disease that affects millions of people worldwide. We investigate the mechanisms involved in NLRP3 activation and demonstrate that caspase-11 (CASP11) is activated in response to infection by...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: de Carvalho, Renan V.H., Andrade, Warrison A., Lima-Junior, Djalma S., Dilucca, Marisa, de Oliveira, Caroline V., Wang, Kun, Nogueira, Paula M., Rugani, Jeronimo N., Soares, Rodrigo P., Beverley, Stephen M., Shao, Feng, Zamboni, Dario S.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022207/
https://ncbi.nlm.nih.gov/pubmed/30625325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.047
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