Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

Progress in our understanding of MR1-restricted mucosa-associated invariant T (MAIT) cells has raised interest in harnessing these cells for immunotherapy. The innate-like response characteristics, abundance in the blood, donor-unrestricted nature, and tropism for tissues make MAIT cells suitable ca...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Parrot, Tiphaine, Healy, Katie, Boulouis, Caroline, Sobkowiak, Michał J., Leeansyah, Edwin, Aleman, Soo, Bertoletti, Antonio, Sällberg Chen, Margaret, Sandberg, Johan K.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2021
Subjects:
Technical Advance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021122/
https://ncbi.nlm.nih.gov/pubmed/33561009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140074
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