Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions

BACKGROUND & AIMS: Virus-specific T cell dysfunction is a common feature of HBV-related hepatocellular carcinoma (HBV-HCC). Conventional T (ConT) cells can be redirected towards viral antigens in HBV-HCC when they express an HBV-specific receptor; however, their efficacy can be impaired by liver...

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Veröffentlicht in:JHEP Rep
Hauptverfasser: Healy, Katie, Pavesi, Andrea, Parrot, Tiphaine, Sobkowiak, Michał J., Reinsbach, Susanne E., Davanian, Haleh, Tan, Anthony T., Aleman, Soo, Sandberg, Johan K., Bertoletti, Antonio, Sällberg Chen, Margaret
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327138/
https://ncbi.nlm.nih.gov/pubmed/34377970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhepr.2021.100318
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