JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice

Osteoclasts are specialized cells of the hematopoietic lineage that are responsible for bone resorption and play a critical role in musculoskeletal disease. JAK2 is a key mediator of cytokine and growth factor signaling; however, its role in osteoclasts in vivo has yet to be investigated. To elucida...

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Publicado en:JCI Insight
Autores principales: Dodington, David W., Yumol, Jenalyn L., Yang, Jiaqi, Pollock-Tahiri, Evan, Sivasubramaniyam, Tharini, Sacco, Sandra M., Schroer, Stephanie A., Li, Yujin E., Le, Helen, Ward, Wendy E., Woo, Minna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021113/
https://ncbi.nlm.nih.gov/pubmed/33682794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137045
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