The pentose phosphate pathway mediates hyperoxia-induced lung vascular dysgenesis and alveolar simplification in neonates

Dysmorphic pulmonary vascular growth and abnormal endothelial cell (EC) proliferation are paradoxically observed in premature infants with bronchopulmonary dysplasia (BPD), despite vascular pruning. The pentose phosphate pathway (PPP), a metabolic pathway parallel to glycolysis, generates NADPH as a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Gong, Jiannan, Feng, Zihang, Peterson, Abigail L., Carr, Jennifer F., Lu, Xuexin, Zhao, Haifeng, Ji, Xiangming, Zhao, You-Yang, De Paepe, Monique E., Dennery, Phyllis A., Yao, Hongwei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021105/
https://ncbi.nlm.nih.gov/pubmed/33497360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137594
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg