Hormonal Modulation of ESR1 Mutant Metastasis

Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer (MBC), and confer clinical resistance to aromatase inhibitors (AIs). Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migratio...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Gu, Guowei, Tian, Lin, Herzog, Sarah K., Rechoum, Yassine, Gelsomino, Luca, Gao, Meng, Du, Lili, Kim, Jin-Ah, Dustin, Derek, Lo, Hin Ching, Beyer, Amanda R., Edwards, David G., Gonzalez, Thomas, Tsimelzon, Anna, Huang, Helen J., Fernandez, Natalie M., Grimm, Sandra L., Hilsenbeck, Susan G., Liu, Dan, Xu, Jun, Alaniz, Alyssa, Li, Shunqiang, Mills, Gordon B., Janku, Filip, Kittler, Ralf, Zhang, Xiang H.-F., Coarfa, Cristian, Foulds, Charles E., Symmans, W. Fraser., Andò, Sebastiano, Fuqua, Suzanne A.W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020875/
https://ncbi.nlm.nih.gov/pubmed/33323970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01563-x
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