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A role for keratin 17 during DNA damage response and tumor initiation

High levels of the intermediate filament protein keratin 17 (K17) are associated with poor prognoses for several human carcinomas. Studies in mouse models have shown that K17 expression is positively associated with growth, survival, and inflammation in skin and that lack of K17 delays onset of tumo...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Nair, Raji R., Hsu, Joshua, Jacob, Justin T., Pineda, Christopher M., Hobbs, Ryan P., Coulombe, Pierre A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020757/
https://ncbi.nlm.nih.gov/pubmed/33762306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020150118
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